Endocrine Abstracts

Background: NMDAR-Ab mediated encephalitis is a neuro-immunological disorder that presents with seizures. NMDAR-Abs cause internalisation of NMDARs while Pregnenolone sulfate (PregS) a neurosteroid upregulates NMDARs in the brain. Our previous in vitro studies have shown that PregS can reduce established ictal activity caused by NMDAR-Abs (Wright et al., 2021). Before proceeding with in vivo treatment studies, we aimed to determine baseline brain PregS levels...